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Analytical Science and Medical Diagnostics

Course details

University Name
The Open University
Department
Department of Chemistry and Analytical Science
Course Title
Analytical Science and Medical Diagnostics
Qualification, duration, mode
PhD 36FT 72PT variableDL*MPhil 15FT 24PT variableDL
Months of entry
October
Entry requirements
PhD: The normal minimum entrance requirement is an upper second class honours degree or master's degree, relevant to the proposed area of study, from a recognised higher education institution in the UK. You should also have experience of academic research in the previous four years, normally in the form of either a master's degree in research methods, an undergraduate degree with a research element in the final year, or work-related experience with evidence through research reports. If you're not sure if you meet the entry requirements, please contact us (research-degrees-team@open.ac.uk).
MPhil: see http://www3.open.ac.uk/study/research-degrees/ for more information.
Funding
Please see The Open University website http://www3.open.ac.uk/study/research-degrees/ for more information.
Course description
Claire Turner uses SIFT MS as an ultrasensitive method for identifying and quantifying volatile organic compounds that are diagnostics for states of ill-health. Current work involves TB and Clostridium difficile infection, as well as markers associated with autism. Maria Velasco applies biosensor technology, using detection systems that encompass antibody and aptamer methodologies (the latter in collaboration with Missailidis), to detect non-volatile markers of disease. Nick Turner develops molecular imprinted polymers to investigate topics ranging from environmental trace chemical analysis to pathways of protein folding. Vic Pearson, in collaboration with colleagues in PSSRI/CEPSAR, is developing immunochemical and fluorescent tagging methods to investigate organic molecules of extra-terrestrial origin.

Potential research projects
- Biosensor technology for the screening of cancer risk biomarkers related to diet.
- Field-based biosensors for the detection of key biomarkers in animal health.
- Volatile biomarker profiles associated with tuberculosis and the development of a novel diagnostic method.
-- Can marker compounds in breath be used to diagnose C.difficile infections'
- Molecular imprinting of proteins - recognition between isoforms, and directed folding of secondary structure.
- Sensor design - In-situ monitoring of industrial processes.
- Trace chemical analysis in environmental samples using functionalised polymers.
- The development and application of nano-conjugates to organic geochemistry.
- Probing the chemistry of space: immunochemical techniques for extraterrestrial samples.
- Aptamer-based biosensors for diagnostic applications.
- Luminescent sensors for medical imaging and diagnosis.
- Design and synthesis of zero background fluorescent sensors.

Potential supervisors
- Dr James Bruce
- Dr Sotiris Missailidis
- Dr Victoria Pearson
- Dr Claire Turner
- Dr Nick Turner
- Dr Maria Velasco
Contact name
Astrid Peterkin
Telephone
+44 (0)1908 659845
Email
science-phd-enquiries@open.ac.uk
Web
http://www3.open.ac.uk/study/research-degrees/

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