Research course

Pathophysiology and Repair

Institution
Cardiff University · School of Biosciences
Qualifications
MPhilPhDMD

Entry requirements

1st or Upper 2nd class UK honours degree or equivalent. MSc/MPhil for PhD Programme.

Months of entry

January, October, July, April

Course content

Pathophysiology and Repair focuses on the molecular mechanisms underpinning physiology, disease and the processes that drive repair and regeneration. The Division has a broad strength that spans biochemistry, cell biology, molecular genetics and signal transduction. The groups within Pathophysiology and Repair focus on a variety of biological systems both in vivo and in vitro, and augment studies on human cell lines and tissues with studies in model organisms such as the mouse and Xenopus.

Pathophysiology and Repair is a well-funded Division with excellent modern facilities for a broad range of techniques. It has close links with The European Cancer Stem Cell Research Institute, the Cardiff Institute of Tissue Engineering and Repair (CITER), the Arthritis Research UK Biomechanics and Bioengineering Centre and also with the Cardiff CR-UK Cancer Centre. The Division also has numerous global academic and industrial partners.

Research within the Division is relevant to several areas of human disease, but is particularly strongly linked to cancer and tissue repair. The spectrum of research activities include:

  • Genetically engineered murine models of human cancer
  • Epigenetics of normal development and disease
  • Mammary cancer and cell death
  • Stem/progenitor cells in mammalian organogenesis
  • Pathophysiology of calcium signalling specifically related to pancreatitis
  • Stem cell fate determination
  • Inflammation, atherosclerosis and regulation of gene expression
  • Molecular mechanisms of nutrient sensing
  • Monoclonal antibody technologies to study onset of degenerative joint diseases
  • Synovial joint biology
  • Structure and function of the minor collagens of cartilage, cell signalling pathways associated with mechanical and cytokine-mediated cartilage degeneration
  • Cartilage proteoglycan metabolism in osteoarthritis
  • Cellular control of extracellular matrix secretion and organisation in connective tissues
  • Signalling mechanisms regulating bone and cartilage turnover, in osteoporosis, rheumatoid arthritis and osteoarthritis
  • How Epigenetic Marks direct Mammalian Development and drive Human Disease
  • Connective tissue mechanobiology
  • Functional significance of synuclein proteins in the normal and degenerating nervous system
  • Investigation of cell death mechanisms
  • Cell fate determination in Xenopus
  • Elucidating the function of lysosomes in health and disease
  • The role of normal mammary stem and progenitor cells in the generation of breast cancer phenotypic heterogeneity and cancer stem cells
  • Cell preservation technology
  • Development of autologous cell-based methods for repair of the degenerate nervous and immune systems
  • Molecular mechanisms mediating channel regulation by reversible protein phosphorylation and mechanisms underlying volume regulation
  • Morphogenetic mechanisms in the organisation of oriented connective tissues

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Information for international students

Applicants whose first language is not English are normally expected to meet the minimum University requirements (e.g. 6.5 IELTS).

Qualification and course duration

MPhil

part time
24-36 months
full time
24 months

PhD

full time
36-48 months
part time
60 months

MD

part time
36 months
full time
24 months

Course contact details

Name
Mrs Swapna Khandavalli
Email
biosi-pg@cardiff.ac.uk
Phone
+44 90)29 2087 5243
Fax
+44 (0)29 2087 5211