Research course

Cell and molecular biomedicine

Institution
Open University · Department of Life Sciences
Qualifications
MPhilPhD

Entry requirements

Minimum 2:1 (or equivalent) or an appropriate first degree and postgraduate qualification

Months of entry

October

Course content

Our research focuses on the molecular and cellular processes underlying health, ageing and disease. We have a particular focus on diseases that have a significant impact on society. Our aim is to identify both novel therapeutic targets and innovative therapeutic agents for these conditions.

Key themes of our research include:

  • Anti-cancer therapies
  • Ageing
  • Appetite and reproductive physiology
  • Cardiovascular disorders, including those affecting the cerebrovascular network such as multiple sclerosis and stroke, and those affecting the heart such as cardiac arrhythmias
  • Cell signaling and systems biology
  • Inflammation and immunity
  • Mechanisms underlying ageing at the organismal and cellular level
  • Molecular mechanisms of disease.

Potential research projects

Current/recent research projects

  • Regulation of cellular autophagic and apoptotic cell death
  • Werner Syndrome-related exonucleases in Drosophila; roles in nuclear and mitochondrial genome stability
  • Changes in signaling and ultra-structure in cardiomyocytes during ageing
  • Developing tissue engineered implantable devices for surgical repair of the nervous system
  • Analysis of changes in gastrointestinal appetite hormones and hypothalamic circuitry during pregnancy and lactation
  • Development of novel, robust 3D CNS tissue models for neurobiological studies and drug discovery
  • The response of human brain and endothelium and astrocytes to vasoactive mediators
  • Elucidating the molecular mechanisms contributing to blood-brain barrier breakdown in multiple sclerosis

Potential supervisors

Department specialisms

- Anti-cancer therapies - Ageing - Appetite and reproductive physiology - Cardiovascular disorders, including those affecting the cerebrovascular network such as multiple sclerosis and stroke, and those affecting the heart such as cardiac arrhythmias - Cell signaling and systems biology - Inflammation and immunity - Mechanisms underlying ageing at the organismal and cellular level - Molecular mechanisms of disease.

Fees and funding

For detailed information on current fees visithttp://www.open.ac.uk/postgraduate/research-degrees/fees-and-funding

Qualification and course duration

MPhil

full time
15 months
distance learning
variable months
part time
24 months

PhD

distance learning
variable months
full time
36 months
part time
72 months

Course contact details

Name
Administrative support
Email
science-phd-enquiries@open.ac.uk
Phone
+44 (0)1908 659036