Research course

Cell Matrix Research

Institution
The University of Manchester · Faculty of Life Sciences
Qualifications
PhDMPhil

Entry requirements

The standard entry requirement for MPhil study is a First or Upper Second class honours degree, or the overseas equivalent, in a relevant subject. The standard entry requirement for PhD study is a First or Upper Second class honours degree, or the overseas equivalent, in a relevant subject. In certain circumstances, a Lower Second class honours degree supplemented by a Masters degree, or appropriate relevant work experience, may be acceptable.

Months of entry

January, April, July, September

Course content

The molecular mechanisms that determine survival, differentiation and movement in multicellular organisms are dependent on interactions with the extracellular matrix (ECM). Cells in tissues are structurally and functionally integrated with their surrounding ECM via numerous dynamic connections. On the intracellular face of these linkages, adhesion receptors tether the contractile cytoskeleton to the plasma membrane and compartmentalise cytoplasmic signalling events, while at the extracellular face, the same receptors direct the deposition of the ECM itself. Such membrane-proximal functions in turn trigger distal processes, such as alterations in the direction of cell movement and the regulation of cell fate, and the construction of ECM networks and consequent shaping of higher order tissue structure. An understanding of the molecular events that underpin ECM function would therefore help elucidate some of the key organising principles of multicellular life.

Information for international students

Students whose first language is not English require a minimum score of 6.5 IELTS, 577 TOEFL (paper), 233 TOEFL (computer), 90 TOEFL (internet).

Qualification and course duration

PhD

full time
36-48 months
part time
72-96 months

MPhil

full time
12 months
part time
24 months

Course contact details

Name
Faculty of Life Sciences Postgraduate Research Office
Email
pgresearch.lifesciences@manchester.ac.uk
Phone
+44 (0) 161 275 5608
Fax
+44 (0) 161 275 5657