Research course

Integrative Cardiovascular and Metabolic Physiology and Pharmacology

University of Nottingham · School of Biomedical Sciences

Entry requirements

For MRes courses applicants are expected to hold a 2:2 (or international equivalent) in a relevant subject. For PhD options applicants are expected to hold a 2:1 (or international equivalent) in a relevant subject.

Months of entry

January, December, November, October, September, August, July, June, May, April, March, February

Course content

The programme consists of a combination of research skills training provided by the Faculty of Medicine and Health Sciences Postgraduate Training Programme, together with supervised independent research, leading to completion of a PhD or a Masters by Research (MRes) thesis. Our students enjoy expert supervision, extensive training, leading-edge facilities, strong industrial links with major pharma companies and the opportunity to undertake short commercial placements. The school encourages students to present their own original research as abstracts and oral and/or poster communications within the school and at national and international scientific meetings.

The aim of research students is to use integrated systems approaches to answer questions of clinical relevance relating to:

  • Endothelium: mechanistic studies of endothelial function in health and disease; paracrine and autocrine regulatory roles of the endothelium, specifically the effects of vasoactive factors such as NO, EDHF, endothelins and VEGF, and their interactions with gap junctions.
  • Placenta: placental function in normal and complicated pregnancies (IUGR, pre-eclampsia, diabetes) including quantitation of diffusive conductance, angiogenesis and trophoblast turnover using design-based stereology; ex vivo perfusion and molecular markers are used to define barrier and angiogenesis function.
  • Neurohumoral Effectors: cardiovascular biology of angiotensins, vasopressin, novel peptides, purines, melatonin, and cannabinoids, in relation to vascular control, receptor mechanisms and post-receptor coupling.
  • Endotoxaemia: quantitative assessment of vasodilator and vasoconstrictor mechanisms in endotoxemia, including cardiovascular/metabolic interactions.
  • Energy Utilisation and Fatigue in Skeletal Muscle: the role of the pyruvate dehydrogenase complex (PDC), and of intramuscular carbohydrate, creatine, carnitine and lipid, on muscle function and fatigue development during contraction.
  • Skeletal Muscle Atrophy and Growth: investigations of molecular events in skeletal muscle relating to atrophy, growth and contraction; skeletal muscle development.
  • Human Energy and Macronutrient Metabolism: studies of carbohydrate utilisation at rest and during exercise; alterations in substrate use in obesity, diabetes and varied meal patterns in relation to insulin sensitivity and thermogenesis; factors regulating appetite and nutrient intake.
  • Nutrient-Gene Interactions: the integrated effects of dietary fat and carbohydrate and dietary components, such as isothiocyanates, on the production, processing and actions of specific transcription factors that regulate gene expression.

For a more extensive overview, please visit the course page on the University of Nottingham's online prospectus.

Information for international students

English language requirements: IELTS 6.5 (no less than 6.0 in any element).

Fees and funding

The Graduate School at The University of Nottingham provides information on internal and external sources of postgraduate funding.

There is also funding information on the School of Life Sciences web pages.

For information on funding opportunities for international students, please see the International Office website

Qualification and course duration


part time
72 months
full time
36 months


full time
24 months
part time
48 months


part time
72 months
full time
36 months


full time
12 months
part time
24 months

Course contact details

Postgraduate Enquiries
+44 (0)115 748 6500