Research course

Cell Matrix Research

Institution
The University of Manchester · Faculty of Biology, Medicine and Health
Qualifications
PhDMPhil

Entry requirements

We require applicants to hold, or be about to obtain, an Upper Second class Honours degree (or overseas equivalent) in a related subject area for entry to a PhD programme. A Lower Second class Honours degree may be considered if applicants also hold a Master's degree with a Merit classification.

Months of entry

January, July, September

Course content

Our PhD/MPhil Cell Matrix Research programme enables you to undertake a research project that will improve understanding of the interactions between cells and their extracellular matrix environment in the contexts of health, disease and tissue regeneration.

Cells continuously sense, synthesise and remodel the proteins and glycosaminoglycans that form the Extracellular Matrix (ECM). This ECM varies in its biochemical and biophysical properties in different parts of the body, and cellular responses to these differences influence the motility, growth, differentiation and survival of cells. Therefore, cell-ECM interactions underpin the development of multicellular organisms and are essential throughout the life of an organism.

Aberrations in cell-matrix communication with severe diseases, such as cancer, fibrosis, cardiovascular disease, and inflammatory disorders. Conversely, the synthesis of healthy matrix can be used to induce new functional tissue that can support regeneration. Because understanding how cells sense and synthesise their ECM is critically important for preventing disease and supporting tissue regeneration, our Cell Matrix postgraduate research programme comprises projects that study:

  • The biochemistry and biophysical properties of the ECM.
  • The mechanisms of how cells interact with the ECM and how they translate the extracellular information into a cellular response
  • How cell-matrix interactions affect cell fate and tissue function;
  • The mechanisms of how cells synthesise and remodel their ECM environment, including how aberrant signals affect health and can result in disease;
  • How ECM signalling can be used for tissue regeneration.

See the Wellcome Trust Centre for Cell-Matrix Research website for further information.

Qualification, course duration and attendance options

  • PhD
    full time
    36-48 months
    • Campus-based learningis available for this qualification
  • MPhil
    full time
    12 months
    • Campus-based learningis available for this qualification
    part time
    24 months
    • Campus-based learningis available for this qualification

Course contact details

Name
Faculty of Biology, Medicine and Health
Email
admissions.doctoralacademy@manchester.ac.uk
Phone
+44 (0) 161 275 5608