Research course

Medical Epigenomics (specialisation)

Institution
Radboud University · Faculty of Science
Qualifications
MSc by research

Entry requirements

Please find all the relevant information about admission requirements on our website.

Months of entry

September

Course content

The only Master’s specialisation in the Netherlands covering the function of our epigenome, a key factor in regulating gene expression and in a wide range of diseases.

Our skin cells, liver cells and blood cells all contain the same genetic information. Yet these are different types of cells, each performing their own specific tasks. How is this possible? The explanation lies in the epigenome: a heritable, cell-type specific set of chromosomal modifications, which regulates gene expression. Radboud University is specialised in studying the epigenome and is the only university in the Netherlands to offer a Master’s programme in Medical Epigenomics.

Health and disease

The epigenome consists of small and reversible chemical modifications of the DNA or histone proteins, such as methylation, acetylation and phosphorylation. It changes the spatial structure of DNA, resulting in gene activation or repression. These processes are crucial for our health and also play a role in many diseases, like autoimmune diseases, cancer and neurological disorders. As opposed to modifications of the genome sequence itself, epigenetic modifications are reversible. You can therefore imagine the great potential of drugs that target epigenetic enzymes, so-called epi-drugs.

Big data

In this specialisation, you’ll look at a cell as one big and complex system. You’ll study epigenetic mechanisms during development and disease from different angles. This includes studying DNA and RNA by next-generation sequencing (epigenomics) and analysing proteins by mass spectrometry (proteomics). In addition, you‘ll be trained to design computational strategies that allow the integration of these multifaceted, high-throughput data sets into one system.

Qualification and course duration

MSc by research

full time
24 months

Course contact details

Name
Admission Office
Email
admissionoffice@ru.nl