Research course

Basic Dental Science

Institution
The University of Manchester · School of Dentistry
Qualifications
PhDMPhil

Entry requirements

Applicants are expected to hold, or about to obtain, an Upper Second class Honours degree (or equivalent) in a related subject area. A Lower Second class Honours degree may be considered if applicants also hold a Masters degree with a Merit classification.

Months of entry

September, April

Course content

Basic dental sciences is a large area covering craniofacial genetics, stem cell biology and craniofacial development.

Craniofacial genetics

We aim to understand the normal developmental mechanisms underlying craniofacial morphogenesis and how these are disturbed in a variety of birth defects.

Group research has identified genetic mutations underlying craniofacial malformations, including Treacher Collins syndrome, Van der Woude syndrome, amelogenesis imperfecta, and dentine dysplasia.

These findings have contributed to quality-of-life improvements as they have impacted directly on clinical management of affected families by providing the basis for genetic counselling internationally.

Stem cell biology

We use human embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and cancer-derived stem cells (CSCs) to study the function of adhesion molecules in development, tumorigenesis and cancer cell metastasis.

The group has demonstrated that ESC differentiation is associated with an epithelial-mesenchymal transition (EMT) event that exhibits striking similarities to tumour cell metastasis.

The Ward group is based in state-of-the-art laboratories that include a dedicated facility for the derivation of human induced pluripotent stem cells (iPSC).

Craniofacial development

We study the regulation of gene expression in cranial neural crest development and differentiation. Changes in gene expression instruct the formation of organs and body parts during development and are mainly regulated at the transcriptional level.

The group has made important contributions to the understanding of the gene regulatory networks that control the formation of diverse cranial neural crest derivatives, including the middle and outer ear and the heart circulation.

Information for international students

For applicants whose first language is not English, you must supply an official IELTS or TOEFL transcript to support your application, or provide a date on which you will be taking a test. Please note the IELTS and TOEFL are only valid for two years.

For the majority of PhD/MPhil applicants, we require a minimum IELTS score of 6.5 overall [or TOEFL (paper) 577, (internet) 90]. Each component of the English test should meet the minimum requirement of IELTS 5.5 in all components, TOEFL (paper 527, internet 72).

Fees and funding

Funded programmes and projects are promoted throughout the year. Funding is available through UK Research Councils, charities and industry. We also have other internal awards and scholarships for the most outstanding applicants.

For more information on available funding, visit our funding opportunities page.

Qualification and course duration

PhD

full time
36 months
part time
72 months

MPhil

full time
12 months
part time
24 months

Course contact details

Phone
+44 (0)161 275 5608